SBI-0206965

SBI-0206965 is a potent, selective and cell permeable autophagy kinase ULK1 inhibitor. It inhibits ULK1 kinase with IC₅₀ of 108 nM and the highly related kinase ULK2 with IC₅₀ of 711 nM. SBI-0206965 suppresses ULK1-mediated phosphorylation events in cells, regulating autophagy and cell survival. SBI-0206965 greatly synergizes with mechanistic target of rapamycin (mTOR) inhibitors to kill tumor cells.