SLMP53-1

SLMP53-1 is a wild-type and mutant p53 reactivator with promising antitumor activity. SLMP53-1 mediates the reprograming of glucose metabolism in cancer cells. SLMP53-1 depletes angiogenesis, decreasing endothelial cell tube formation and vascular endothelial growth factor (VEGF) expression levels[1][2].

Product Specifications

CAS Number

[1643469-17-3]

UNSPSC

12352005

Target

MDM-2/p53

Type

Reference compound

Related Pathways

Apoptosis

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/slmp53-1.html

Purity

99.25

Solubility

DMSO : 250 mg/mL (ultrasonic; warming; heat to 80°C)

Smiles

O=C1N2[C@@](OC[C@@H]2CC3=CNC4=C3C=CC=C4)(C)C5=C1C=CC=C5

Molecular Formula

C20H18N2O2

Molecular Weight

318.37

References & Citations

[1]Gomes S, et al. SLMP53-2 Restores Wild-Type-Like Function to Mutant p53 through Hsp70: Promising Activity in Hepatocellular Carcinoma. Cancers (Basel) . 2019 Aug 10;11 (8) :1151.|[2]Ramos H, et al. SLMP53-1 Inhibits Tumor Cell Growth through Regulation of Glucose Metabolism and Angiogenesis in a P53-Dependent Manner. Int J Mol Sci. 2020 Jan 17;21 (2) :596.