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GW-3965 hydrochloride

GW-3965 hydrochloride is a non-steroidal liver X receptor agonist on hLXRα and hLXRβ. GW3965 has an EC₅₀ = 125 nM in a cell-free ligand-sensing assay of LXRα and profiles as a full agonist on hLXRα and hLXRβ in cell-based assays with EC₅₀ = 190 nM and 30 nM, respectively. Up-regulates ABCA1 gene expression and raises circulating HDL levels. Displays potent antiatherogenic activity in mouse models of atherosclerosis.

Product Specifications

Shipping Conditions

gel pack

Storage Conditions

-20°C

Shelf Life

36 months

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