Ritlecitinib
Product Specifications
UNSPSC Description
Ritlecitinib (PF-06651600) is an orally active and selective JAK3 inhibitor with an IC50 of 33.1 nM[1].
Target Antigen
JAK
Type
Reference compound
Related Pathways
Epigenetics;JAK/STAT Signaling;Protein Tyrosine Kinase/RTK;Stem Cell/Wnt
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/PF-06651600.html
Purity
99.80
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
C=CC(N1[C@@H](C)CC[C@@H](NC2=C3C(NC=C3)=NC=N2)C1)=O
Molecular Weight
285.351
References & Citations
[1]Telliez JB, et al. Discovery of a JAK3-Selective Inhibitor: Functional Differentiation of JAK3-Selective Inhibition over pan-JAK or JAK1-Selective Inhibition. ACS Chem Biol. 2016 Dec 16;11(12):3442-3451.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-100754/Ritlecitinib-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-100754/Ritlecitinib-SDS-MedChemExpress.pdf
Clinical Information
Launched
CAS Number
1792180-81-4
Available Sizes
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
MBS6134997-01 0.1 mL
ZIC4 (Zic Family Member 4, Zinc Family Member 4 Protein HZIC4, Zinc finger Protein of the Cerebellum 4, FLJ42609, FLJ45833) (AP)
Ask
View Details 
MBS6134997-02 5x 0.1 mL
ZIC4 (Zic Family Member 4, Zinc Family Member 4 Protein HZIC4, Zinc finger Protein of the Cerebellum 4, FLJ42609, FLJ45833) (AP)
Ask
View Details 
IHUANXA1RTFLY50UG 50 µg
Human Annexin A1 Recombinant Protein Tag Free Lyophilized 50UG
Ask
View Details