PF-04554878

PF-04554878 is potent, ATP-competitive, focal adhesion kinase (FAK) inhibitor with potential antiangiogenic and antineoplastic activities. PF-04554878 inhibits FAK phosphorylation at the Tyr397 site in a time- and dose-dependent manner.  A combination of PF-04554878 and paclitaxel markedly decreases proliferation and increases apoptosis.