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GSK2830371

GSK2830371 is an allosteric Wip1 (Wild type p53-induced phosphatase) inhibitor (IC₅₀ of 6 nM). It binds to a flap subdomain that regulates Wip1's enzymatic activity and substrate recognition. Due to lack of this domain in other phosphatases, its binding to GSK2830371 results in a selective and potent inhibition of Wip1. Treatment of tumor cells with the inhibitor GSK2830371 increases phosphorylation of Wip1 substrates and causes growth inhibition in both hematopoietic tumor cell lines and Wip1-amplified breast tumor cells harboring wild-type TP53.

Product Specifications

Shipping Conditions

Gel pack

Storage Conditions

-20°C

Shelf Life

24 months

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HSD3B2 (3 beta HSD adrenal and gonadal Type, 3 beta HSD II, 3 beta HSD Type II, 3 beta hydroxy 5 ene steroid Dehydrogenase, 3 beta hydroxy Delta (5) steroid Dehydrogenase, 3 beta hydroxysteroid Dehydrogenase/Delta 5->4-Isomerase Type 2, 3 beta-hydroxysteroid Dehydrogenase Type II, delta 5-delta 4-Isomerase Type II, 3 beta-HSD Type II, 3 beta-hydroxysteroid Dehydrogenase/Delta 5->4-Isomerase Type II, 3 beta-hydroxysteroid Dehydrogenase/Delta 5->4-Isomerase Type 2, 3-beta-HSD II, 3-beta-hydroxy-5-ene steroid Dehydrogenase, 3-beta-hydroxy-Delta (5) -steroid Dehydrogenase, 3BHS2_HUMAN, ADRENAL HYPERPLASIA II, beta-hydroxysteroid Dehydrogenase/Delta 5->4-Isomerase Type 2, delta 5 delta 4 Isomerase Type II, Delta-5-3-ketosteroid Isomerase, HSD3B, HSD3B2, HSDB, HSDB3B, hydroxy delta 5 steroid Dehydrogenase, 3 beta and steroid delta Isomerase 2, Hydroxy-delta-5-steroid Dehydrogenase, 3 beta- and steroid delta-Isomerase 2, Progesterone Reductase, SDR11E2, short Chain Dehydrogenase/Reductase Family 11E, Member 2, Steroid Delta-Isomerase, ) discontinued

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