Aftin-5

Roscovitine-related purine with no activity on CDKS. Selectively and potently increases production of extracellular Aβ42 and decreases production of extracellular Aβ38 in cultured cells. Extracellular Aβ40 levels remain stable. Intracellular levels of these amyloids appear to remain stable. Alzheimer's Disease (AD) accelerator that interacts with VDAC1, prohibitin and mitofilin, possibly interfering with subcellular compartmentalization and lipid rafts properties, shifting γ-secretase activity toward Aβ42 generation. Induces a reversible mitochondrial phenotype reminiscent of the one observed in AD brains.