JZP-361
JZP-361 is a potent, reversible and selective inhibitor of human recombinant MAGL (hMAGL) with an IC50 of 46 nM. JZP-361 also shows antihistaminergic activities and can be used for asthma research[1].
Product Specifications
CAS Number
[1680193-80-9]
UNSPSC
12352005
Target
Histamine Receptor; MAGL
Type
Reference compound
Related Pathways
GPCR/G Protein; Immunology/Inflammation; Metabolic Enzyme/Protease; Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/jzp-361.html
Concentration
10mM
Purity
99.72
Solubility
DMSO : 125 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(N(CC/1)CCC1=C2C3=C(CCC4=C/2N=CC=C4)C=C(C=C3)Cl)N5N=CN=C5
Molecular Formula
C22H20ClN5O
Molecular Weight
405.88
References & Citations
[1]Jayendra Z Patel, et al. Loratadine analogues as MAGL inhibitors. Bioorg Med Chem Lett. 2015 Apr 1;25 (7) :1436-42.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
H1 Receptor
Available Sizes
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