Traut's Reagent

KEY FEATURES & APPLICATIONS: • Water-soluble • Adds a 5-atom spacer arm (8.1 Å) to minimize steric hindrance • The spacer is cleavable at the disulfide bond with reducing agent, such as DTT, TCEP, etc. • Commonly used to convert primary amines into sulfhydryl groups in a one-step process is called thiolation • Amine reactive at pH 7-10 and is also an effective thiolation reagent for polysaccharides • Useful RNA-protein crosslinking reagent.