LV-320
LV-320 is a potent and uncompetitive ATG4B inhibitor with an IC50 of 24.5 ��M and a Kd of 16 μM. LV-320 inhibits ATG4B enzymatic activity, blocks autophagic flux in cells, and is stable, non-toxic and active in vivo[1].
Product Specifications
CAS Number
[2449093-46-1]
UNSPSC
12352005
Target
Atg4; Autophagy
Type
Reference compound
Related Pathways
Autophagy
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/LV-320.html
Purity
95.0
Solubility
DMSO : 135 mg/mL (ultrasonic)
Smiles
ClC1=CC2=NC=CC(/C=C/C3=CC=C(C(SCCC(O)=O)SCCC4=CC=CC=C4)C=C3)=C2C=C1
Molecular Formula
C29H26ClNO2S2
Molecular Weight
520.11
References & Citations
[1]Bosc D, et al. A new quinoline-based chemical probe inhibits the autophagy-related cysteine protease ATG4B. Sci Rep. 2018 Aug 3;8 (1) :11653. doi: 10.1038/s41598-018-29900-x.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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