LV-320

LV-320 is a potent and uncompetitive ATG4B inhibitor with an IC50 of 24.5 ��M and a Kd of 16 μM. LV-320 inhibits ATG4B enzymatic activity, blocks autophagic flux in cells, and is stable, non-toxic and active in vivo[1].

Product Specifications

CAS Number

[2449093-46-1]

UNSPSC

12352005

Target

Atg4; Autophagy

Type

Reference compound

Related Pathways

Autophagy

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/LV-320.html

Purity

95.0

Solubility

DMSO : 135 mg/mL (ultrasonic)

Smiles

ClC1=CC2=NC=CC(/C=C/C3=CC=C(C(SCCC(O)=O)SCCC4=CC=CC=C4)C=C3)=C2C=C1

Molecular Formula

C29H26ClNO2S2

Molecular Weight

520.11

References & Citations

[1]Bosc D, et al. A new quinoline-based chemical probe inhibits the autophagy-related cysteine protease ATG4B. Sci Rep. 2018 Aug 3;8 (1) :11653. doi: 10.1038/s41598-018-29900-x.