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GPRP (acetate)

GPRP acetate (Gly-Pro-Arg-Pro acetate) is a fibrin polymerization inhibitor that inhibits the interaction of fibrinogen with the platelet membrane glycoprotein IIb/IIIa complex (GPIIb/IIIa) [1][2][3].

Product Specifications

CAS Number

157009-81-9

Product Name Alternative

Gly-Pro-Arg-Pro (acetate) ; Pefa 6003 (acetate)

UNSPSC

12352209

Hazard Statement

H302, H315, H319, H335

Target

Integrin

Type

Peptides

Related Pathways

Cytoskeleton

Applications

COVID-19-immunoregulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/GPRP-acetate.html

Purity

98.90

Solubility

H2O : 125 mg/mL

Smiles

CC(O)=O.O=C([C@H]1N(CCC1)C(CN)=O)N[C@@H](CCCNC(N)=N)C(N2[C@@H](CCC2)C(O)=O)=O

Molecular Formula

C20H35N7O7

Molecular Weight

485.53

Precautions

H302, H315, H319, H335

References & Citations

[1]Gallistl S, et al. Gly-pro-arg-pro (GPRP) enhances free thrombin. Thromb Res. 1995 Jun 15;78 (6) :547-50.|[2]Hsieh KH, et, al. Fibrin Polymerization. 1. Alkylating peptide inhibitors of fibrin polymerization. J Med Chem. 1981 Mar; 24 (3) : 322-7.|[3]Zhang C, et al. Fibrinogen/AKT/Microfilament Axis Promotes Colitis by Enhancing Vascular Permeability. Cell Mol Gastroenterol Hepatol. 2021;11 (3) :683-696.

Shipping Conditions

Blue Ice

Storage Conditions

-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

Scientific Category

Peptides

Clinical Information

No Development Reported

Citation 01

Cell Mol Gastroenterol Hepatol. 2021;11 (3) :683-696.|Platelets. 2025 Dec;36 (1) :2517108.|Res Pract Thromb Haemost. 2025 Sep 24.

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