Question 1

What is the catalog number for GDC-0449?

Accepted Answer

The catalog number for GDC-0449 is 1890-25.

Question 2

Is GDC-0449 in stock?

Accepted Answer

GDC-0449 is currently made to order / not held in immediate stock. Contact us for lead time.

Question 3

What is GDC-0449 used for?

Accepted Answer

A potent inhibitor of Smoothened (SMO), a key mediator of Hedgehog (Hh) signaling pathway. Inhibition of SMO renders the transcription factor GLI inactive, thus preventing the expression of genes that mediate the role of Hh on tumor growth.

Question 4

What is the molecular weight of the target protein?

Accepted Answer

Molecular weight information, where applicable, is listed on the datasheet under target details, useful for confirming the correct band on western blot.

Question 5

How long will it take to receive this product if it’s custom made?

Accepted Answer

Lead times depend on the product type: custom polyclonal antibodies typically take 12-14 weeks, monoclonal antibodies 15-17 weeks, made-to-order recombinant proteins 4-8 weeks, and made-to-order recombinant antibodies 6-8 weeks. These are estimates and may shift due to production delays.

Question 6

What is the recommended dilution for this antibody?

Accepted Answer

A recommended dilution range for each validated application is provided on the datasheet, but optimal dilution should be titrated for your specific experimental system, sample type, and detection method.

GDC-0449

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