HADA (hydrochloride)

HADA hydrochloride (HCC-Amino-D-alanine hydrochloride) is a blue (λem~450 nm) fluorescent D-amino acid (FDAA) . FDAAs are efficiently incorporated into the peptidoglycans (PGs) of diverse bacterial species at the sites of PG biosynthesis, allowing specific and covalent probing of bacterial growth with minimal perturbation[1].

Product Specifications

CAS Number

[2253733-10-5]

Product Name Alternative

HCC-Amino-D-alanine (hydrochloride)

UNSPSC

12171500

Hazard Statement

H302+H312+H332-H315-H319-H335

Target

Bacterial

Type

Dye Reagents

Related Pathways

Anti-infection

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/hada-hydrochloride.html

Purity

99.08

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

N[C@H](CNC(C1=CC2=CC=C(O)C=C2OC1=O)=O)C(O)=O.[H]Cl

Molecular Formula

C13H13ClN2O6

Molecular Weight

328.71

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Erkin Kuru, et al. Synthesis of fluorescent D-amino acids and their use for probing peptidoglycan synthesis and bacterial growth in situ. Nat Protoc. 2015 Jan;10 (1) :33-52.|[2]Xu Q, et al. Phage protein Gp11 blocks Staphylococcus aureus cell division by inhibiting peptidoglycan biosynthesis. mBio. 2024 Jun 12;15 (6) :e0067924.