NVP-TAE684
A potent and selective ALK (anaplastic lymphoma kinase) inhibitor that blocked the growth of ALCL (anaplastic large cell lymphoma)-derived and ALK-dependent cell lines with IC₅₀ = 2-10 nM. NVP-TAE684 treatment resulted in a rapid and sustained inhibition of phosphorylation of NPM-ALK (Nucleophosmin-anaplastic lymphoma kinase) and its downstream effectors and subsequent induction of apoptosis and cell cycle arrest.
Product Specifications
Shipping Conditions
gel pack
Storage Conditions
-20°C
Shelf Life
24 months
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