Wortmannin, Penicillium funiculosum

Potent, selective, cell-permeable and irreversible inhibitor of phosphatidylinositol 3-kinase (PI 3-kinase) (IC₅₀ = 2-4 nM). Also potently inhibits polo-like kinase 1 (PLK1) (IC₅₀ = 5.8 nM).