DNA Polymerase γ (POLG) His-FLAG-tag Recombinant

<strong>DNA Polymerase Œ≥ (POLG) His-FLAG-tag Recombinant</strong>_x000D_ <strong>Catalog number:</strong> B2019051_x000D_ <strong>Lot number:</strong> Batch Dependent_x000D_ <strong>Expiration Date:</strong> Batch dependent_x000D_ <strong>Amount:</strong> 50 µg_x000D_ <strong>Molecular Weight or Concentration:</strong> 141 kDa_x000D_ <strong>Supplied as:</strong> Solution_x000D_ <strong>Applications:</strong> a molecular tool for various biochemical applications_x000D_ <strong>Storage:</strong> ‚àí80¬∞C_x000D_ <strong>Keywords:</strong> DNA polymerase subunit gamma-1, Pol gamma, POLG, PEO, Mitochondrial DNA polymerase catalytic subunit, MDP1, SCAE, MIRAS, POLG1, PolG-alpha, POLGA, SANDO, MTDPS4A, MTDPS4B_x000D_ <strong>Grade:</strong> Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity &gt;18 MŒ©-cm) and are filtered through 0.22 um._x000D_ _x000D_ <strong>References:</strong>_x000D_ 1: Szczepanowska K, Trifunovic A. Origins of mtDNA mutations in ageing Essays Biochem. 2017 Jul 11;61(3):325-337._x000D_ 2: Stumpf JD, Copeland WC. Mitochondrial DNA replication and disease: insights from DNA polymerase Œ≥ mutations Cell Mol Life Sci. 2011 Jan;68(2):219-33._x000D_ 3: Hudson G, Chinnery PF. Mitochondrial DNA polymerase-gamma and human disease Hum Mol Genet. 2006 Oct 15;15 Spec No 2:R244-52._x000D_ 4: Spelbrink JN, Toivonen JM, Hakkaart GA, Kurkela JM, Cooper HM, Lehtinen SK, Lecrenier N, Back JW, Speijer D, Foury F, Jacobs HT. In vivo functional analysis of the human mitochondrial DNA polymerase POLG expressed in cultured human cells J Biol Chem. 2000 Aug 11;275(32):24818-28._x000D_ 5: Chattopadhyay K, Aldous C. A brief review on human mtDNA mutations and NRTI-associated mtDNA toxicity and mutations Mitochondrial DNA A DNA Mapp Seq Anal. 2016 May;27(3):1685-7._x000D_ 6: DeBalsi KL, Longley MJ, Hoff KE, Copeland WC. Synergistic Effects of the in cis T251I and P587L Mitochondrial DNA Polymerase Œ≥ Disease Mutations J Biol Chem. 2017 Mar 10;292(10):4198-4209._x000D_ 7: Darin N, Siibak T, Peter B, Hedberg-Oldfors C, Kollberg G, Kalbin V, Moslemi AR, Macao B, Oldfors A, Falkenberg M. Functional analysis of a novel POLŒ≥A mutation associated with a severe perinatal mitochondrial encephalomyopathy Neuromuscul Disord. 2021 Apr;31(4):348-358._x000D_ 8: Chen R, Wang Z, Lan R, Huang F, Chen J, Xu Y, Zhang H, Zhang L. Influence of POLG on Radiosensitivity of Nasopharyngeal Carcinoma Cells Cancer Biother Radiopharm. 2018 May;33(4):146-154._x000D_ 9: Peeva V, Blei D, Trombly G, Corsi S, Szukszto MJ, Rebelo-Guiomar P, Gammage PA, Kudin AP, Becker C, Altm√ºller J, Minczuk M, Zsurka G, Kunz WS. Linear mitochondrial DNA is rapidly degraded by components of the replication machinery Nat Commun. 2018 Apr 30;9(1):1727._x000D_ <a href="https://pubmed.ncbi.nlm.nih.gov/19478085">10: Kasiviswanathan R, Longley MJ, Chan SS, Copeland WC. Disease mutations in the human mitochondrial DNA polymerase thumb subdomain impart severe defects in mitochondrial DNA replication J Biol Chem. 2009 Jul 17;284(29):19501-10. </a>_x000D_ _x000D_ <strong>Products Related to DNA Polymerase Œ≥ (POLG) His-FLAG-tag Recombinant can be found at</strong> <a href="https://moleculardepot.com/product-category/DNA/"> DNA</a>