Methyl Salicylate

Methyl Salicylate (Wintergreen oil) is a topical analgesic and anti-inflammatory agent. Also used as a pesticide, a denaturant, a fragrance ingredient, and a flavoring agent in food and tobacco products[1]. A systemic acquired resistance (SAR) signal in tobacco[2]. A topical nonsteroidal anti-inflammatory agent (NSAID) . Methyl salicylate lactoside is a COX inhibitor[4].

Product Specifications

CAS Number

[119-36-8]

Product Name Alternative

Salicylic acid methyl ester

UNSPSC

12352005

Hazard Statement

H302, H317, H318, H361, H412

Target

COX

Type

Natural Products

Related Pathways

Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/Methyl_Salicylate.html

Concentration

10mM

Purity

99.98

Solubility

Ethanol : 25 mg/mL (ultrasonic)

Smiles

O=C(OC)C1=CC=CC=C1O

Molecular Formula

C8H8O3

Molecular Weight

152.15

Precautions

H302, H317, H318, H361, H412

References & Citations

[1]Greene T, et al. A critical review of the literature to conduct a toxicity assessment for oral exposure to methyl salicylate. Crit Rev Toxicol. 2017 Feb;47 (2) :98-120.|[2]Park SW, et al. Methyl salicylate is a critical mobile signal for plant systemic acquired resistance. Science. 2007 Oct 5;318 (5847) :113-6.|[3]Lapczynski A, et al. Fragrance material review on methyl salicylate. Food Chem Toxicol. 2007;45 Suppl 1:S428-52.|[4]Xin W, et al. Methyl salicylate lactoside inhibits inflammatory response of fibroblast-like synoviocytes and joint destruction in collagen-induced arthritis in mice. Br J Pharmacol. 2014 Jul;171 (14) :3526-38.