T4 RNA Ligase 2 (dsRNA Ligase)

T4 RNA Ligase 2 (dsRNA Ligase) catalyzes the ATP-dependent formation of a 3’→5’ phosphodiester bond catalyzing intramolecular and intermolecular RNA strand joining. Unlike T4 RNA Ligase 1 (M1218-100) which ligates single-stranded RNA, T4 RNA Ligase 2 joins nicks on double-stranded RNA and can also ligate the 3’OH of RNA to the 5’ phosphate of DNA in a double stranded structure.