RWJ 63556

RWJ 63556 is an orally active COX-2 selective/5-lipoxygenase inhibitor, with anti-inflammatory activities.

Product Specifications

CAS Number

[190967-35-2]

UNSPSC

12352005

Target

COX; Lipoxygenase

Type

Reference compound

Related Pathways

Immunology/Inflammation; Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/RWJ_63556.html

Purity

99.35

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CS(=O)(NC1=CC=C(OC2=CC=C(F)C=C2)S1)=O

Molecular Formula

C11H10FNO3S2

Molecular Weight

287.33

References & Citations

[1]Kirchner T, et al. Evaluation of the antiinflammatory activity of a dual cyclooxygenase-2 selective/5-lipoxygenase inhibitor, RWJ 63556, in a canine model of inflammation. J Pharmacol Exp Ther. 1997 Aug;282 (2) :1094-101.|[2]Le Filliatre G, et al. Cyclo-oxygenase and lipoxygenase pathways in mast cell dependent-neurogenic inflammation induced by electrical stimulation of the rat saphenous nerve. Br J Pharmacol. 2001 Apr;132 (7) :1581-9.