RWJ 63556
RWJ 63556 is an orally active COX-2 selective/5-lipoxygenase inhibitor, with anti-inflammatory activities.
Product Specifications
CAS Number
190967-35-2
UNSPSC
12352005
Target
COX; Lipoxygenase
Type
Reference compound
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/RWJ_63556.html
Purity
99.35
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CS(=O)(NC1=CC=C(OC2=CC=C(F)C=C2)S1)=O
Molecular Formula
C11H10FNO3S2
Molecular Weight
287.33
References & Citations
[1]Kirchner T, et al. Evaluation of the antiinflammatory activity of a dual cyclooxygenase-2 selective/5-lipoxygenase inhibitor, RWJ 63556, in a canine model of inflammation. J Pharmacol Exp Ther. 1997 Aug;282 (2) :1094-101.|[2]Le Filliatre G, et al. Cyclo-oxygenase and lipoxygenase pathways in mast cell dependent-neurogenic inflammation induced by electrical stimulation of the rat saphenous nerve. Br J Pharmacol. 2001 Apr;132 (7) :1581-9.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
5-LOX; COX-2
Available Sizes
Frequently Asked Questions
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