Arg-Gly-Asp-Ser
Product Specifications
Product Name Alternative
RGDS peptide; Fibronectin tetrapeptide
UNSPSC Description
Arg-Gly-Asp-Ser is an integrin binding sequence that inhibits integrin receptor function. Arg-Gly-Asp-Ser directly and specifically bind pro-caspase-8, pro-caspase-9 and pro-caspase-3, while it does not bind pro-caspase-1.
Target Antigen
Integrin
Type
Peptides
Related Pathways
Cytoskeleton
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/Arg-Gly-Asp-Ser.html
Purity
99.93
Solubility
DMSO : 50 mg/mL (ultrasonic)|H2O : ≥ 25 mg/mL
Smiles
O=C(N[C@@H](CO)C(O)=O)[C@H](CC(O)=O)NC(CNC([C@@H](N)CCCNC(N)=N)=O)=O
Molecular Weight
433.42
References & Citations
[1]Grigoriou V, et al. Apoptosis and survival of osteoblast-like cells are regulated by surface attachment. J Biol Chem. 2005 Jan 21;280(3):1733-9.|[2]Moon C, et al. Synthetic RGDS peptide attenuates lipopolysaccharide-induced pulmonary inflammation by inhibiting integrin signaled MAP kinase pathways. Respir Res. 2009 Mar 9;10:18.|[3]Yin X, et al. Synthetic RGDS peptide attenuated lipopolysaccharide/D-galactosamine-induced fulminant hepatic failure in mice. J Gastroenterol Hepatol. 2014 Jun;29(6):1308-15.|[4]Aguzzi MS, et al. Intracellular targets of RGDS peptide in melanoma cells. Mol Cancer. 2010 Apr 22;9:84.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-12290/Arg-Gly-Asp-Ser-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-12290/Arg-Gly-Asp-Ser-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
91037-65-9
Available Sizes
Curated Selection
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