Cas9 Nuclease (10mg/mL)

Cas9 Nuclease, derived from wild-type Streptococcus pyogenes, is an RNA-guided endonuclease capable of specifically cleaving double-stranded DNA (it can also cleave single-stranded DNA or RNA in the presence of DNA PAM). The Cas9 cleavage site is located within the target sequence, three bases away from the PAM (NGG) region. This product, through codon optimization and nuclear localization signal (NLS) design, is recombinantly expressed in Escherichia coli, exhibiting high editing efficiency.