(±) -Huperzine A
(±) -Huperzine A, an active Lycopodium alkaloid extracted from traditional Chinese herb, is a potent, selective and reversible acetylcholinesterase (AChE) inhibitor and has been widely used in China for the treatment of Alzheimer's disease (AD) . IC50 value: Target: AChE (±) -Huperzine A exhibited protective effects against d-gal-induced hepatotoxicity and inflamm-aging by inhibiting AChE activity and via the activation of the cholinergic anti-inflammatory pathway. The (±) -Huperzine A mechanism might be involved in the inhibition of DAMPs-mediated NF-κB nuclear localization and activation. (±) -Huperzine A is a potential therapeutic agent for Alzheimer's disease.
Product Specifications
CAS Number
[120786-18-7]
UNSPSC
12352005
Hazard Statement
H301, H311, H315, H319, H331, H335
Target
Cholinesterase (ChE)
Type
Natural Products
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/__plusmn__-huperzine-a.html
Purity
98.73
Solubility
DMSO : ≥ 50 mg/mL
Smiles
O=C1C=CC(C(/C2=C/C)(N)CC(C)=CC2C3)=C3N1
Molecular Formula
C15H18N2O
Molecular Weight
242.32
Precautions
H301, H311, H315, H319, H331, H335
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
AChE
Available Sizes
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HNF4A, ID (Hepatocyte Nuclear Factor 4-alpha, HNF-4-alpha, Transcription Factor HNF-4, Nuclear Receptor Subfamily 2 Group A Member 1, Transcription Factor 14, HNF4, NR2A1, TCF14) (HRP)
