(±)-Huperzine A
Product Specifications
UNSPSC Description
(±)-Huperzine A, an active Lycopodium alkaloid extracted from traditional Chinese herb, is a potent, selective and reversible acetylcholinesterase (AChE) inhibitor and has been widely used in China for the treatment of Alzheimer's disease (AD).
IC50 value:
Target: AChE
(±)-Huperzine A exhibited protective effects against d-gal-induced hepatotoxicity and inflamm-aging by inhibiting AChE activity and via the activation of the cholinergic anti-inflammatory pathway. The (±)-Huperzine A mechanism might be involved in the inhibition of DAMPs-mediated NF-κB nuclear localization and activation. (±)-Huperzine A is a potential therapeutic agent for Alzheimer's disease.
Target Antigen
Cholinesterase (ChE)
Type
Natural Products
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/__plusmn__-huperzine-a.html
Solubility
DMSO : ≥ 50 mg/mL
Smiles
O=C1C=CC(C(/C2=C/C)(N)CC(C)=CC2C3)=C3N1
Molecular Weight
242.322
References & Citations
[1]Wang J, et al. Huperzine a improves chronic inflammation and cognitive decline in rats with cerebral hypoperfusion. J Neurosci Res. 2010 Mar;88(4):807-15.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-17388/racemic-Huperzine-A-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-17388/racemic-Huperzine-A-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
120786-18-7
Available Sizes
Curated Selection
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