Roxatidine
Roxatidine is an active metabolite of Roxatidine acetate hydrochloride, is an orally active histamine H2-receptor antagonist. Roxatidine, an anti-ulcer agent, suppresses histamine release (thus inhibiting proton secretion) and inhibits the production of VEGF-1, an important marker of inflammation and angiogenesis. Anti-allergic inflammatory effect. Roxatidine is promising for research of gastric and duodenal ulcers[1][2][3].
Product Specifications
CAS Number
78273-80-0
UNSPSC
12352005
Hazard Statement
H302
Target
Caspase; Histamine Receptor; NF-κB; p38 MAPK
Type
Reference compound
Related Pathways
Apoptosis; GPCR/G Protein; Immunology/Inflammation; MAPK/ERK Pathway; Neuronal Signaling; NF-κB
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/roxatidine.html
Purity
98.25
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(NCCCOC1=CC=CC(CN2CCCCC2)=C1)CO
Molecular Formula
C17H26N2O3
Molecular Weight
306.41
Precautions
H302
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
H2 Receptor
Available Sizes
Frequently Asked Questions
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