Cloperastine (hydrochloride)
Cloperastine hydrochloride inhibits the hERG K+ currents in a concentration-dependent manner with an IC50 value of 27 nM[1].
Product Specifications
CAS Number
14984-68-0
UNSPSC
12352005
Hazard Statement
H302
Target
Potassium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/cloperastine-hydrochloride.html
Concentration
10mM
Purity
99.39
Solubility
DMSO : 250 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)
Smiles
ClC1=CC=C(C(C2=CC=CC=C2)OCCN3CCCCC3)C=C1.[H]Cl
Molecular Formula
C20H25Cl2NO
Molecular Weight
366.32
Precautions
H302
References & Citations
[1]Takahara A, et al. Effects of the antitussive drug cloperastine on ventricular repolarization in halothane-anesthetized guinea pigs. J Pharmacol Sci. 2012;120 (3) :165-75.|[2]Catania MA, et al. Pharmacological and clinical overview of cloperastine in treatment of cough. Ther Clin Risk Manag. 2011;7:83-92.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
Launched
Available Sizes
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