6-Thioinosine
6-Thioinosine (6TI) is a purine antimetabolite and an anti-adipogenic agent. 6-Thioinosine reduces the mRNA levels of PPARγ and C/EBPα and downregulates the mRNA levels of PPARγ target genes (LPL, CD36, aP2, and LXRα) . 6-Thioinosine exerts its anti-adipogenic effects by downregulating PPARγ through JNK-dependent iNOS upregulation. 6-Thioinosine can be used to study adipocyte dysfunction[1].
Product Specifications
CAS Number
[574-25-4]
Product Name Alternative
6TI; 6-Mercaptopurine riboside
UNSPSC
12352005
Hazard Statement
H302
Target
JNK; LXR; NO Synthase; PPAR
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Immunology/Inflammation; MAPK/ERK Pathway; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/6-thioinosine.html
Purity
99.31
Solubility
DMSO : 83.33 mg/mL (ultrasonic)
Smiles
S=C1NC=NC2=C1N=CN2[C@H]3[C@H](O)[C@H](O)[C@@H](CO)O3
Molecular Formula
C10H12N4O4S
Molecular Weight
284.30
Precautions
H302
References & Citations
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
INOS; PPARγ
Available Sizes
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