Protein Disulfide Isomerase (PDI) (Mouse) ELISA Kit

Protein Disulfide Isomerases are multifunctional proteins that constitute a thio-disulfide oxidoreductase family. PDI is abundant in the lumen of endoplasmic reticulum and it plays an essential role in catalyzing the rearrangement of disulfide (S-S) bonds in proteins and functions as a chaperone by inhibiting protein aggregation. Recent studies show that PDI activity is essential for cancer cell survival and proliferation, and targeting PDI activity with specific inhibitors abrogates survival responses leading to ER stress in cancer cells. Therefore, the detection of PDI activity is critical for mechanistic study, diagnosis, prevention, and therapeutic purposes. BioVision’s Protein Disulfide Isomerase ELISA kit is a sandwich ELISA assay for the quantitative measurement of mouse PDI in serum, plasma and cell culture supernatants. The density of color is proportional to the amount of mouse PDI captured from the samples.