Atrial Natriuretic Peptide (ANP) ELISA Kit

Atrial Natriuretic Peptide (ANP) is derived from a 151 amino acid long protein called preproANP3. The preproprotein is cleaved to generate pro-ANP. This principle storage form of the peptide is the pro-ANP form which is 126 amino acids long. ANP is derived from amino acids 99-126 to form the 28 amino acid peptide with a disulfide bond between amino acids 7 and 23. ANP is the predominant member of a family of structurally and functionally related peptide hormones that exert a wide array of effects on cardiovascular and renal function. The combined actions of ANP on vasculature, kidneys, and adrenals serve both acutely and chronically to reduce systemic blood pressure as well as intravascular volume. ANP and the related brain natriuretic peptide bind to their common receptor, membrane-type guanylyl cyclase-A and binding leads to biological actions through a cGMP-dependent pathway. BioVision’s ANP ELISA kit is a competitive ELISA assay for the quantitative measurement of ANP in extracted serum and plasma, or in urine, extracted dried fecal samples, and tissue culture media samples.