17-Hydroxyprogesterone ELISA Kit

The adrenal glands, ovaries, testes, and placenta produce 17-hydroxyprogesterone. It is hydroxylated at the 11 and 21 position to produce cortisol. Deficiency of either 11- or 21-hydroxylase results in decreased cortisol synthesis, and feedback inhibition of adrenocorticotropic hormone (ACTH) secretion is lost. Consequent increased pituitary release of ACTH will increase production of 17-HOP. But, if 17-alpha-hydroxylase (which allows formation of 17-HOP from progesterone) or 3ß-hydroxysteroid dehydrogenase type 2 (which allows formation of 17-hydroxyprogesterone formation from 17-hydroxypregnenolone) are deficient, 17-HOP levels are low with possible increase in progesterone or pregnenolone respectively. BioVision’s 17-Hydroxyprogesterone ELISA kit is a competitive ELISA assay for the quantitative measurement of 17-Hydroxyprogesterone in extracted serum and plasma, or in urine, extracted dried fecal samples, and tissue culture media samples.