Chlorhexidine (digluconate) (20% in water)

Chlorhexidine digluconate (20% in water) is a orally active cationic antimicrobial agent that targets microbial cell membranes. Chlorhexidine digluconate (20% in water) binds to cell membrane phospholipids non-specifically, destroys membrane structure and induces leakage of cell contents. Chlorhexidine digluconate (20% in water) has broad-spectrum bactericidal activity against both Gram-positive and Gram-negative bacteria. Chlorhexidine digluconate (20% in water) can interfere with membrane permeability, cause protein precipitation and energy metabolism disorders, such as rapid inhibition of microbial growth and induction of cell death (necrosis or apoptosis) [1][2][3].

Product Specifications

CAS Number

[18472-51-0]

UNSPSC

12352005

Hazard Statement

H302, H312, H332

Target

Antibiotic; Apoptosis; Bacterial; Necroptosis

Type

Reference compound

Related Pathways

Anti-infection; Apoptosis

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/chlorhexidine-digluconate.html

Purity

99.45

Solubility

DMSO : ≥ 250 mg/mL|H2O : 100 mg/mL (ultrasonic)

Smiles

N=C(NC(NCCCCCCNC(NC(NC1=CC=C(Cl)C=C1)=N)=N)=N)NC2=CC=C(Cl)C=C2.O[C@H]([C@@H](O)C(O)=O)[C@H](O)[C@H](O)CO.O[C@H]([C@@H](O)C(O)=O)[C@H](O)[C@H](O)CO

Molecular Formula

C34H54Cl2N10O14

Molecular Weight

897.76

Precautions

H302, H312, H332

References & Citations

[1]Faria G, et al. Evaluation of chlorhexidine toxicity injected in the paw of mice and added to cultured l929 fibroblasts. J Endod. 2007 Jun;33 (6) :715-22.|[2]Zhang J, et al. Pulmonary Toxicity Assessment after a Single Intratracheal Inhalation of Chlorhexidine Aerosol in Mice. Toxics. 2023 Nov 7;11 (11) :910.|[3]Sanchez IR, et al. Chlorhexidine diacetate and povidone-iodine cytotoxicity to canine embryonic fibroblasts and Staphylococcus aureus. Vet Surg. 1988;17 (4) :182-185.|[4]Ribeiro DA, et al. Chlorhexidine induces DNA damage in rat peripheral leukocytes and oral mucosal cells. J Periodontal Res. 2004 Oct;39 (5) :358-61.