SHP-2, Human (T253M, Q257L, His)
The SHP-2 protein is a key player downstream of the receptor and cytoplasmic protein tyrosine kinases, facilitating signal transduction from the cell surface to the nucleus. It actively regulates the MAPK pathway and dephosphorylates key substrates, including GAB1, ARHGAP35, EGFR, ROCK2 ("Tyr-722"), and CDC73. SHP-2 Protein, Human (T253M, Q257L, His) is the recombinant human-derived SHP-2 protein, expressed by E. coli , with N-6*His labeled tag and T253M, Q257L mutation.
Product Specifications
Product Name Alternative
SHP-2 Protein, Human (T253M, Q257L, His), Human, E. coli
UNSPSC
12352202
Type
Recombinant Proteins
Assay Protocol
https://www.medchemexpress.com/cytokines/ptpn11-protein-t253m-q257l-his.html
Purity
98.00
Smiles
Molecular Formula
5781 (Gene_ID) Q06124-2 (T2-R593, T253M, Q257L) (Accession)
Molecular Weight
Approximately 70-75 kDa
Shipping Conditions
Room temperature in continental US; may vary elsewhere.
Storage Conditions
Stored at -20°C for 2 years
Scientific Category
Recombinant Proteins
Available Sizes
Frequently Asked Questions
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