SHP-2, Human (T253M, Q257L, His)

The SHP-2 protein is a key player downstream of the receptor and cytoplasmic protein tyrosine kinases, facilitating signal transduction from the cell surface to the nucleus. It actively regulates the MAPK pathway and dephosphorylates key substrates, including GAB1, ARHGAP35, EGFR, ROCK2 ("Tyr-722"), and CDC73. SHP-2 Protein, Human (T253M, Q257L, His) is the recombinant human-derived SHP-2 protein, expressed by E. coli , with N-6*His labeled tag and T253M, Q257L, , , mutation. The total length of SHP-2 Protein, Human (T253M, Q257L, His) is 592 a.a., with molecular weight of 70-75 kDa.

TSRRWFHPNI TGVEAENLLL TRGVDGSFLA RPSKSNPGDF TLSVRRNGAV THIKIQNTGD YYDLYGGEKF ATLAELVQYY MEHHGQLKEK NGDVIELKYP LNCADPTSER WFHGHLSGKE AEKLLTEKGK HGSFLVRESQ SHPGDFVLSV RTGDDKGESN DGKSKVTHVM IRCQELKYDV GGGERFDSLT DLVEHYKKNP MVETLGTVLQ LKQPLNTTRI NAAEIESRVR ELSKLAETTD KVKQGFWEEF EMLQQLECKL LYSRKEGQRQ ENKNKNRYKN ILPFDHTRVV LHDGDPNEPV SDYINANIIM PEFETKCNNS KPKKSYIATQ GCLQNTVNDF WRMVFQENSR VIVMTTKEVE RGKSKCVKYW PDEYALKEYG VMRVRNVKES AAHDYTLREL KLSKVGQGNT ERTVWQYHFR TWPDHGVPSD PGGVLDFLEE VHHKQESIMD AGPVVVHCSA GIGRTGTFIV IDILIDIIRE KGVDCDIDVP KTIQMVRSQR SGMVQTEAQY RFIYMAVQHY IETLQRRIEE EQKSKRKGHE YTNIKYSLAD QTSGDQSPLP PCTPTPPCAE MREDSARVYE NVGLMQQQKS FR