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Sefaxersen sodium

Sefaxersen sodium is a specific antisense oligonucleotide (ASO) targeting complement factor B (CFB) . Sefaxersen sodium effectively reduces circulating levels of CFB, and can be used for geographic atrophy (GA) research[1][2].

Product Specifications

CAS Number

2272983-11-4

Product Name Alternative

IONIS-FB-LRx sodium; RG6299 sodium; ISIS 696844 sodium

UNSPSC

12352208

Target

Complement System

Type

Oligonucleotides

Related Pathways

Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/ionis-fb-lrx-sodium.html

Purity

93.90

Solubility

H2O : 100 mg/mL (ultrasonic)

Smiles

[Sefaxersensodium]

Molecular Weight

8678.96 (free acid)

References & Citations

[1]Dreismann AK, et al. Gene targeting as a therapeutic avenue in diseases mediated by the complement alternative pathway. Immunol Rev. 2022 Nov 12.|[2]Mahmoudzadeh R, et al. Emerging treatments for geographic atrophy in age-related macular degeneration. Curr Opin Ophthalmol. 2021 May 1;32 (3) :294-300.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C (Powder, sealed storage, away from moisture)

Scientific Category

Oligonucleotides

Clinical Information

Phase 2

Available Sizes

Frequently Asked Questions

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