Diethyl pyrocarbonate

Diethyl pyrocarbonate is a potent, orally active, non-specific chemical inhibitor of RNase. Diethyl pyrocarbonate has been useful in vitro as an agent relatively specific for binding to imidazole of histidine. Diethyl pyrocarbonate inhibits central chemosensitivity in rabbits. Diethyl pyrocarbonate can modify Ser, Thr, His and Tyr residues. Diethyl pyrocarbonate can be used for modeling[1].

Product Specifications

CAS Number

[1609-47-8]

UNSPSC

12352200

Hazard Statement

H302

Target

Biochemical Assay Reagents

Type

Biochemical Assay Reagents

Related Pathways

Others

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/diethyl-pyrocarbonate.html

Purity

99.66

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : ≥ 33.33 mg/mL

Smiles

CCOC(OC(OCC)=O)=O

Molecular Formula

C6H10O5

Molecular Weight

162.14

Precautions

H302

References & Citations

[1]E E Nattie. Diethyl pyrocarbonate (an imidazole binding substance) inhibits rostral VLM CO2 sensitivity. J Appl Physiol (1985) . 1986 Sep;61 (3) :843-50.|[2]Uzvölgyi E, et al. In vivo formation of a carcinogenic substance from diethyl pyrocarbonate in the presence of ammonia. Arch Toxicol Suppl. 1985;8:490-3.