JJH260

JJH260 is AIG1inhibitor, and inhibit the fluorophosphonate reactivity and fatty acid esters of hydroxy fatty acid (FAHFA) hydrolysis activity of AIG1in HEK293T cells, with IC50 values of 0.50 μM and 0.57 μM, respectively[1].

Product Specifications

CAS Number

[1831135-30-8]

Product Name Alternative

AG-013736

UNSPSC

12352005

Target

Androgen Receptor; MAGL

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/jjh260.html

Concentration

10mM

Purity

98.05

Solubility

DMSO : 6.25 mg/mL (ultrasonic)

Smiles

CN(C1=CC=C(C(N2CCN(C3C2)C(N(C3=O)OC(N4CCC(CC4)CCC5=CC=C(C=C5)Cl)=O)=O)=O)C=C1)C

Molecular Formula

C29H34ClN5O5

Molecular Weight

568.06

References & Citations

[1]William H Parsons, et al. AIG1 and ADTRP are atypical integral membrane hydrolases that degrade bioactive FAHFAs. Nat Chem Biol. 2016 May;12 (5) :367-372.|[2]Xinkang Wang, et al. Antithrombotic Effects of the Novel Small-Molecule Factor XIa Inhibitor Milvexian in a Rabbit Arteriovenous Shunt Model of Venous Thrombosis. TH Open. 2023 Apr; 7 (2) : e97–e104.