BPK-21

BPK-21, an active acrylamide, suppresses T cell activation through blockade of ERCC3 function. BPK-21 specifically targets C342 in the helicase ERCC3[1].

Product Specifications

CAS Number

[2305052-77-9]

UNSPSC

12352005

Target

Others

Type

Reference compound

Related Pathways

Others

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/bpk-21.html

Purity

99.56

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

C=CC(N(CC1=CC=CC(Cl)=C1Cl)C2=CC=C(OC3=CC=CC=C3)C(C(F)(F)F)=C2)=O

Molecular Formula

C23H16Cl2F3NO2

Molecular Weight

466.28

References & Citations

[1]Ekaterina V Vinogradova, et al. An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182 (4) :1009-1026.e29.