BPK-21
BPK-21, an active acrylamide, suppresses T cell activation through blockade of ERCC3 function. BPK-21 specifically targets C342 in the helicase ERCC3[1].
Product Specifications
CAS Number
[2305052-77-9]
UNSPSC
12352005
Target
Others
Type
Reference compound
Related Pathways
Others
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/bpk-21.html
Purity
99.56
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
C=CC(N(CC1=CC=CC(Cl)=C1Cl)C2=CC=C(OC3=CC=CC=C3)C(C(F)(F)F)=C2)=O
Molecular Formula
C23H16Cl2F3NO2
Molecular Weight
466.28
References & Citations
[1]Ekaterina V Vinogradova, et al. An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182 (4) :1009-1026.e29.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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