Steviol

Steviol is the main metabolite of steviol glycosides and an inhibitor of AQP2/CFTR. Steviol slows down the growth of renal cysts by inhibiting the activity of CFTR, reducing the expression of AQP2, and promoting the degradation of AQP2 and CFTR. Steviol can be used in the research of polycystic kidney disease[1][2].

Product Specifications

CAS Number

[471-80-7]

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

Aquaporin; CFTR; Chloride Channel

Type

Natural Products

Related Pathways

Membrane Transporter/Ion Channel

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/steviol.html

Purity

99.85

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

C[C@@]1(C(O)=O)CCC[C@@]2(C)[C@@]3([H])[C@@]4(CC([C@@](CC3)(O)C4)=C)CC[C@]12[H]

Molecular Formula

C20H30O3

Molecular Weight

318.45

Precautions

H302, H315, H319, H335

References & Citations

[1]Noitem R, et al. Steviol slows renal cyst growth by reducing AQP2 expression and promoting AQP2 degradation. Biomed Pharmacother. 2018 May;101:754-762.|[2]Melis MS, et al. Steviol effect, a glycoside of Stevia rebaudiana, on glucose clearances in rats. Braz J Biol. 2009 May;69 (2) :371-4.