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TP-808

TP-808 is an intermediate used in tetracycline antibiotic synthesis with antimicrobial activity. TP-808 binds to the 30S ribosome subunit of the bacteria, preventing aminoacyl-trNA from entering the A site, thereby inhibiting the extension of the protein chain. TP-808 can be used in antibiotic drug development research[1].

Product Specifications

CAS Number

852821-06-8

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Bacterial

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/tp-808.html

Concentration

10mM

Purity

99.72

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

CC(C)(C)[Si](C)(C)O[C@]12[C@](CC=CC2=O)([H])[C@@H](C3=C(C(OCC4=CC=CC=C4)=NO3)C1=O)N(C)C

Molecular Formula

C26H34N2O5Si

Molecular Weight

482.64

Precautions

H302, H315, H319, H335

References & Citations

[1]Clark RB, et al. Synthesis and biological evaluation of 8-aminomethyltetracycline derivatives as novel antibacterial agents. J Med Chem. 2013 Oct 24;56 (20) :8112-38.|[2]Zhang W Y, et al. Process research and development of TP-808: a key intermediate for the manufacture of synthetic tetracyclines[J]. Organic Process Research & Development, 2017, 21 (3) : 377-386.

Shipping Conditions

Room Temperature

Storage Conditions

Store at room temperature 3 years

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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