Propoxur-d3

Propoxur-d3 is the deuterated form of Propoxur (HY-B0916) . Propoxur is a reversible, competitive, orally active AChE inhibitor that can cross the blood-brain barrier. Propoxur inhibits AChE activity to induce neurotoxicity, while promoting MMP-2 expression and enhancing tumor cell migration and invasion by inducing intracellular ROS generation and activating the ERK/Nrf2 signaling pathway. On the one hand, Propoxur inhibits AChE, leading to acetylcholine accumulation and causing neurological dysfunction; on the other hand, it promotes Nrf2 nuclear translocation through ROS-dependent ERK1/2 phosphorylation, and upregulates MMP-2 and other invasion-related proteins. Propoxur is also a carbamate insecticide used to combat turf, forestry, and household pests[1][2][3][4].

Product Specifications

CAS Number

[1219798-56-7]

UNSPSC

12352005

Target

Cholinesterase (ChE) ; ERK; Insecticide; Isotope-Labeled Compounds; Keap1-Nrf2; MMP; Reactive Oxygen Species (ROS)

Type

Isotope-Labeled Compounds

Related Pathways

Immunology/Inflammation; MAPK/ERK Pathway; Metabolic Enzyme/Protease; Neuronal Signaling; NF-κB; Others; Stem Cell/Wnt

Field of Research

Cancer; Infection; Neurological Disease

Solubility

10 mM in DMSO

Smiles

O=C(NC([2H])([2H])[2H])OC1=C(OC(C)C)C=CC=C1

Molecular Formula

C11H12D3NO3

Molecular Weight

212.26

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-223.|[2]Shi Y, et al. Propoxur enhances MMP-2 expression and the corresponding invasion of human breast cancer cells via the ERK/Nrf2 signaling pathway. Oncotarget. 2017 Jul 7;8 (50) :87107-87123.|[3]Maran E, et al. Effects of aldicarb and propoxur on cytotoxicity and lipid peroxidation in CHO-K1 cells. Food Chem Toxicol. 2010 Jun;48 (6) :1592-6.|[4]Mohamadin A M, et al. Protective effects of Nigella sativa oil on propoxur-induced toxicity and oxidative stress in rat brain regions[J]. Pesticide biochemistry and physiology, 2010, 98 (1) : 128-134.