HS-276
Product Specifications
UNSPSC Description
HS-276 is an orally active, potent and highly selective TAK1 inhibitor, with a Ki of 2.5 nM. HS-276 shows significant inhibition of TAK1, CLK2, GCK, ULK2, MAP4K5, IRAK1, NUAK, CSNK1G2, CAMKKβ-1, and MLK1, with IC50 values of 8.25, 29, 33, 63, 125, 264, 270, 810, 1280, and 5585 nM, respectively. HS-276 can be used for rheumatoid arthritis (RA) research[1].
Target Antigen
Casein Kinase; IRAK; TNF Receptor
Type
Reference compound
Related Pathways
Apoptosis;Cell Cycle/DNA Damage;Immunology/Inflammation;Stem Cell/Wnt
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/hs-276.html
Solubility
DMSO : 50 mg/mL (ultrasonic;warming;adjust pH to 2 with 1M HCl;heat to 60°C)
Smiles
O=C(C1=CC=CC(C(NC2=NC3=C(N2CCC)C=C(CN4CCCCC4)C=C3)=O)=C1)N
Molecular Weight
419.52
References & Citations
[1]Scarneo S, et al. Development and Efficacy of an Orally Bioavailable Selective TAK1 Inhibitor for the Treatment of Inflammatory Arthritis. ACS Chem Biol. 2022 Mar 18;17(3):536-544.
Shipping Conditions
Blue Ice
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-147141/HS-276-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-147141/HS-276-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
2767422-72-8
Available Sizes
Curated Selection
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