Sulfo-ara-F-NMN

Sulfo-ara-F-NMN (CZ-48) is a mimetic of nicotinamide mononucleotide (NMN) . Sulfo-ara-F-NMN acts selectively, activating SARM1 but inhibiting CD38 (IC50 around 10 μM) . Sulfo-ara-F-NMN induces intracellular cyclic ADP-ribose (cADPR) production[1].

Product Specifications

CAS Number

[1374663-29-2]

Product Name Alternative

CZ-48

UNSPSC

12352005

Target

Toll-like Receptor (TLR)

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/sulfo-ara-f-nmn.html

Purity

99.36

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)

Smiles

O=C(N)C1=CC=C[N+]([C@@H]2O[C@H](COP([O-])(O)=S)[C@@H](O)[C@@H]2F)=C1

Molecular Formula

C11H14FN2O6PS

Molecular Weight

352.28

References & Citations

[1]Zhao ZY, et al. A Cell-Permeant Mimetic of NMN Activates SARM1 to Produce Cyclic ADP-Ribose and Induce Non-apoptotic Cell Death. iScience. 2019 May 31;15:452-466.