SB-743921 (hydrochloride)
SB-743921 hydrochloride is a potent inhibitor of the mitotic kinesin KSP (Eg5), with a Ki of 0.1 nM.
Product Specifications
CAS Number
940929-33-9
UNSPSC
12352005
Hazard Statement
H317, H319
Target
Kinesin
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/SB-743921.html
Purity
99.76
Solubility
DMSO : ≥ 100 mg/mL|H2O : 10 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
ClC1=CC2=C(C(C(CC3=CC=CC=C3)=C([C@@H](C(C)C)N(C(C4=CC=C(C=C4)C)=O)CCCN)O2)=O)C=C1.Cl
Molecular Formula
C31H34Cl2N2O3
Molecular Weight
553.52
Precautions
H317, H319
References & Citations
[1]Jeffrey R. Jackson, et al. A second generation KSP inhibitor, SB-743921, is a highly potent and active therapeutic in preclinical models of cancer. First AACR International Conference on Molecular Diagnostics in Cancer Therapeutic Development, Sep 12-15, 2006.|[2]Yin Y, et al. Kinesin spindle protein inhibitor SB743921 induces mitotic arrest and apoptosis and overcomes imatinib resistance of chronic myeloid leukemia cells. Leuk Lymphoma. 2015 Jun;56 (6) :1813-20.|[3]Good JA, et al. Optimized S-trityl-L-cysteine-based inhibitors of kinesin spindle protein with potent in vivo antitumor activity in lung cancer xenograft models. J Med Chem. 2013 Mar 14;56 (5) :1878-93.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
Kinesin-5/Eg5/KSP
Available Sizes
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