SB-743921 (hydrochloride)

SB-743921 hydrochloride is a potent inhibitor of the mitotic kinesin KSP (Eg5), with a Ki of 0.1 nM.

Product Specifications

CAS Number

[940929-33-9]

UNSPSC

12352005

Hazard Statement

H317, H319

Target

Kinesin

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Cytoskeleton

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/SB-743921.html

Purity

99.76

Solubility

DMSO : ≥ 100 mg/mL|H2O : 10 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

ClC1=CC2=C(C(C(CC3=CC=CC=C3)=C([C@@H](C(C)C)N(C(C4=CC=C(C=C4)C)=O)CCCN)O2)=O)C=C1.Cl

Molecular Formula

C31H34Cl2N2O3

Molecular Weight

553.52

Precautions

H317, H319

References & Citations

[1]Jeffrey R. Jackson, et al. A second generation KSP inhibitor, SB-743921, is a highly potent and active therapeutic in preclinical models of cancer. First AACR International Conference on Molecular Diagnostics in Cancer Therapeutic Development, Sep 12-15, 2006.|[2]Yin Y, et al. Kinesin spindle protein inhibitor SB743921 induces mitotic arrest and apoptosis and overcomes imatinib resistance of chronic myeloid leukemia cells. Leuk Lymphoma. 2015 Jun;56 (6) :1813-20.|[3]Good JA, et al. Optimized S-trityl-L-cysteine-based inhibitors of kinesin spindle protein with potent in vivo antitumor activity in lung cancer xenograft models. J Med Chem. 2013 Mar 14;56 (5) :1878-93.