EGFR-IN-87
EGFR-IN-87 (Compound Example 2) is a EGFR tyrosine kinase inhibitor. EGFR-IN-87 has IC50 value of 3.1 nM, 1.3 nM and 7.1 nM for EGFR_d746-750, EGFR_L858R/T790 and EGFR_WT in A431 cells, respectively. EGFR-IN-87 can be used for cancer diseases research[1].
Product Specifications
CAS Number
[1835666-87-9]
UNSPSC
12352005
Target
EGFR
Type
Reference compound
Related Pathways
JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/egfr-in-87.html
Solubility
10 mM in DMSO
Smiles
O=C(NC1=CC(NC2=NC=CC(N3C=C(C)C4=C3C=CC=C4)=N2)=C(C=C1N(CCN(C)C)C)OC)C=C
Molecular Formula
C28H33N7O2
Molecular Weight
499.61
References & Citations
[1]Song Y.T, et al. Selective inhibitors of clinically important mutants of the egfr tyrosine kinase. The United States, WO2017120429 A1. 2017-07-13.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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