UGT8-IN-1
UGT8-IN-1 is a brain penetrable and orally active inhibitor of ceramide galactosyltransferase enzyme (UGT8) . UGT8-IN-1 can be used in the study for lysosomal storage disorders[1].
Product Specifications
CAS Number
[2414349-93-0]
UNSPSC
12352005
Hazard Statement
H315, H319, H320
Target
UGT
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/ugt8-in-1.html
Purity
99.94
Solubility
DMSO : 115 mg/mL (ultrasonic)
Smiles
O=C(OC1CCN(C2=CC(C(F)(F)F)=C3C(C(C(NC)=O)=CS3)=N2)CC1)N[C@@H](C)COC(F)(F)F
Molecular Formula
C20H22F6N4O4S
Molecular Weight
528.47
Precautions
H315, H319, H320
References & Citations
[1]Sukanthini Thurairatnam, et al. Brain Penetrable Inhibitors of Ceramide Galactosyltransferase for the Treatment of Lysosomal Storage Disorders. ACS Med Chem Lett. 2020 Jun 16;11 (10) :2010-2016.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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