ONO-AE3-208 (sodium salt)
ONO-AE3-208 (sodium salt) is a selective and orally active EP4 receptor antagonist with a Ki of 1.3 nM. ONO-AE3-208 (sodium salt) shows less potently affects EP3, FP, and TP receptors (Ki of 30 nM, 790 nM, and 2400 nM, respectively) . ONO-AE3-208 (sodium salt) suppresses cell invasion, migration, and metastasis of prostate cancer[1][2].
Product Specifications
CAS Number
2309931-05-1
Product Name Alternative
AE 3-208 (sodium salt)
UNSPSC
12352005
Target
Prostaglandin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Field of Research
Cancer; Endocrinology
Smiles
FC1=CC=C(C2=CC=CC=C21)C(C)C(NC3=CC(C#N)=CC=C3CCCC(O[Na])=O)=O
Molecular Formula
C24H20FN2NaO3
Molecular Weight
426.42
References & Citations
[1]Kenji Kabashima, et al. The prostaglandin receptor EP4 suppresses colitis, mucosal damage and CD4 cell activation in the gut. J Clin Invest. 2002 Apr;109 (7) :883-93.|[2]Ren Y, et al. Prostaglandin E2 mediates connecting tubule glomerular feedback. Hypertension. 2013 Dec;62 (6) :1123-8.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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