RO4987655
RO4987655 is an orally active and highly selective MEK inhibitor with an IC50 of 5.2 nM for inhibition of MEK1/MEK2.
Product Specifications
CAS Number
874101-00-5
Product Name Alternative
CH4987655
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
MEK
Type
Reference compound
Related Pathways
MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/RO4987655.html
Purity
99.01
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
FC(C(F)=C(NC1=CC=C(I)C=C1F)C(C(NOCCO)=O)=C2)=C2CN3C(CCCO3)=O
Molecular Formula
C20H19F3IN3O5
Molecular Weight
565.28
Precautions
H302, H315, H319, H335
References & Citations
[1]Lee L, et al. The safety, tolerability, pharmacokinetics, and pharmacodynamics of single oral doses of CH4987655 in healthy volunteers: target suppression using a biomarker. Clin Cancer Res. 2009 Dec 1;15 (23) :7368-74.|[2]Tegnebratt T, et al. Evaluation of efficacy of a new MEK inhibitor, RO4987655, in human tumor xenografts by [ (18) F] FDG-PET imaging combined with proteomic approaches. EJNMMI Res. 2014 Dec;4 (1) :34.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 1
Isoform
MEK1; MEK2
Available Sizes
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