RO4987655

RO4987655 is an orally active and highly selective MEK inhibitor with an IC50 of 5.2 nM for inhibition of MEK1/MEK2.

Product Specifications

CAS Number

[874101-00-5]

Product Name Alternative

CH4987655

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

MEK

Type

Reference compound

Related Pathways

MAPK/ERK Pathway

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/RO4987655.html

Purity

99.01

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

FC(C(F)=C(NC1=CC=C(I)C=C1F)C(C(NOCCO)=O)=C2)=C2CN3C(CCCO3)=O

Molecular Formula

C20H19F3IN3O5

Molecular Weight

565.28

Precautions

H302, H315, H319, H335

References & Citations

[1]Lee L, et al. The safety, tolerability, pharmacokinetics, and pharmacodynamics of single oral doses of CH4987655 in healthy volunteers: target suppression using a biomarker. Clin Cancer Res. 2009 Dec 1;15 (23) :7368-74.|[2]Tegnebratt T, et al. Evaluation of efficacy of a new MEK inhibitor, RO4987655, in human tumor xenografts by [ (18) F] FDG-PET imaging combined with proteomic approaches. EJNMMI Res. 2014 Dec;4 (1) :34.